How is it possible for the NBE serums to penetrate the skin during treatment?

There are a few factors of importance: 
1.    The phospholipid structure is equal to the bilayer structure of the skin.   (double aqua/lipid bilayer).
This means that our skin accepts it as being skin identical.

2.    The light augmentation of temperature will transform the phospholipid in a liquid crystal which will act than as a so-called micelle.

3.    The active ingredients are all selected on molecular weight and are all below 500 Kdalton if penetration is required.  If no penetration is required, the size will be over 1500 Kdalton. 

4.    At the end of the treatment, we are making use of an occlusive mask which again will favorize the penetration.

5.    Some ingredients are encapsulated in vesicles which can release the active ingredient at the place where it should be released avoiding so that too much of the active is oxidized before it reached the target area.  (For your information about 75 % of most active ingredients are getting oxidized once reached the skin.)